Abstract
A novel class of 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones possessing a central six-membered lactone (pyran-2-one) ring system, in conjunction with C-6 alkyl (Me, Et or i-Pr), alkoxy (OMe, OEt or O-i-Pr), and alkylthio (SMe, SEt or S-i-Pr) substituents, were designed for evaluation as selective COX-2 inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemical synthesis*
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Alkanes / pharmacology*
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Binding Sites / drug effects
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Cyclooxygenase 1
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / chemical synthesis*
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Cyclooxygenase Inhibitors / pharmacology*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology*
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Hydrogen Bonding
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Indicators and Reagents
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Isoenzymes / metabolism*
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Prostaglandin-Endoperoxide Synthases / metabolism*
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Pyrones / chemical synthesis*
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Pyrones / pharmacology*
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Structure-Activity Relationship
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Sulfones / chemical synthesis*
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Sulfones / pharmacology*
Substances
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Alkanes
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Heterocyclic Compounds
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Indicators and Reagents
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Isoenzymes
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Pyrones
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Sulfones
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Cyclooxygenase 1
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases